Redox protection by bacterial glutathione peroxidase drives virulence in Pseudomonas aeruginosa

Redox Report 2026 Open access

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Authors: J Silva Cordeiro, Thiago Macêdo Lopes Correia, Igor Pereira Ribeiro Muniz, Railmara Pereira da Silva, Talita Costa dos Santos, Leonardo Silva Rocha, Regiane Yatsuda, Júlia de Oliveira Borges, Álbert S. Peixoto, Amélia Cristina Mendes de Magalhães, Robson Amaro Augusto da Silva, Flávia Carla Meotti
+1 more Raphael Ferreira Queiroz
DOI: 10.1080/13510002.2026.2676357
Cited by: 1
References: 72

Abstract

BACKGROUND: relies on antioxidant enzymes to withstand host-derived oxidative stress during infection. Here, we investigated the role of bacterial glutathione peroxidase (GPx) in survival and virulence of the PA14 strain under inflammatory conditions associated with hyperuricemia. METHODS: strains to assess bacterial burden, inflammation, oxidative damage, and survival. RESULTS: resistance to oxidative killing and promoting virulence. CONCLUSION: .

Fields of Study & Subjects

Neutrophil Myeloperoxidase and Oxidative Mechanisms Redox biology and oxidative stress Selenium in Biological Systems

Publication details

Journal / source
Redox Report
Publisher
Informa UK Limited
Volume
31
Issue
1
Pages
2676357–2676357
Publication date
22 May 2026
Language
EN