Albumin as a dynamic extracellular redox regulator: from Cys34 oxidation biomarkers to polysulfide-mediated homeostatic mechanisms and clinical applications
Abstract
> 1) across multiple intramolecular cysteine bridges. Quantified using the newly developed Elimination Method for Sulfide from Polysulfide, albumin polysulfides are dynamically regulated by oxidative stress and are significantly depleted in chronic kidney disease and early hepatitis, even when conventional Cys34-based markers remain unchanged. Polysulfide depletion impairs both Site II drug-binding capacity and reactive oxygen species scavenging activity, with direct implications for pharmacokinetics and therapeutic efficacy. These findings collectively reframe HSA as a dynamic polysulfide reservoir and extracellular redox regulator, highlighting albumin polysulfide modulation as a compelling emerging therapeutic strategy.
Fields of Study & Subjects
Sulfur Compounds in Biology
Redox biology and oxidative stress
Endoplasmic Reticulum Stress and Disease
Publication details
- Journal / source
- Redox Report
- Publisher
- Informa UK Limited
- Volume
- 31
- Issue
- 1
- Pages
- 2682043–2682043
- Publication date
- 2 June 2026
- Language
- EN