Type III intermediate filaments as novel CoAlation targets
Abstract
Type III intermediate filaments, such as vimentin, GFAP, and desmin, are involved in cell mechanics, signaling, and stress responses, and are tightly regulated by posttranslational modifications (PTMs). The monomers of these proteins possess a single cysteine residue that plays a key role in network remodeling under oxidative stress. CoAlation is a PTM involving mixed disulfide bond formation between a protein thiol and the coenzyme A (CoA) thiol. Here we aim to investigate the potential CoAlation of vimentin, GFAP, and desmin, and its functional consequences.
Fields of Study & Subjects
Skin and Cellular Biology Research
Neurological diseases and metabolism
RNA regulation and disease
Publication details
- Journal / source
- DIGITAL.CSIC (Spanish National Research Council (CSIC))
- Publisher
- Informa UK Limited
- Volume
- 31
- Issue
- 1
- Publication date
- 24 June 2026
- Language
- EN