Association between the uric acid-to-HDL-cholesterol ratio and diabetic kidney disease in individuals with type 2 diabetes and NAFLD: evidence from NHANES and an external hospital cohort
Abstract
BACKGROUND: Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Nonalcoholic fatty liver disease (NAFLD) frequently coexists with T2DM and may increase metabolic and renal vulnerability. The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) is a composite metabolic marker, but its association with DKD in T2DM with NAFLD remains unclear. RESEARCH DESIGN AND METHODS: We analyzed 797 adults with T2DM and CAP-defined NAFLD from NHANES 2017-2018 and 202 hospitalized adults with ultrasound-confirmed NAFLD. Kidney outcome was defined as eGFR
Fields of Study & Subjects
Gout
Hyperuricemia
Uric Acid
Diabetes
Cardiovascular Risks
and Lipoproteins
Diet
Metabolism
and Disease
Publication details
- Journal / source
- Expert Review of Molecular Diagnostics
- Publisher
- Informa UK Limited
- Volume
- 26
- Issue
- 4
- Pages
- 363–371
- Publication date
- 3 April 2026
- Language
- EN