Design, synthesis, anticancer activity, and mechanistic investigation of 4,5,6,7-tetrahydrobenzo[ b ]thiophene carboxamides as CDK-2 inhibitors: in vitro and in silico DFT and molecular docking study

Journal of Enzyme Inhibition and Medicinal Chemistry 2026 Open access

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Authors: Kurls E. Anwer, Ramadan M. Ramadan, Eman S. Nossier, Najla Altwaijry, Asmaa Saleh, Stefan Bräse, Ebtehal M. Husseiny
DOI: 10.1080/14756366.2026.2656826
Cited by: 1
References: 61

Abstract

displayed the highest CDK-2 inhibition, exceeding roscovitine by nearly threefold. Besides, it arrested the MDA-MB-231 cell cycle at the G0/G1 phase by apoptotic stimulation. Molecular modelling showed strong binding of the bioactive analogues to the active pocket of CDK-2 receptor, suggesting their potential as lead inhibitors.

Fields of Study & Subjects

Synthesis and biological activity Cancer-related Molecular Pathways Synthesis of heterocyclic compounds

Publication details

Journal / source
Journal of Enzyme Inhibition and Medicinal Chemistry
Publisher
Informa UK Limited
Volume
41
Issue
1
Pages
2656826–2656826
Publication date
29 May 2026
Language
EN