Do maternal and neonatal outcomes differ with single or twin pregnancies affected by hypertensive disorders? A systematic review and meta-analysis
Abstract
OBJECTIVE: To compare maternal and neonatal outcomes of singleton and twin gestations complicated by hypertensive disorders of pregnancy (HDP). METHODS: PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Google Scholar were searched for comparative studies till 15th May 2025. RESULTS: Thirteen studies were included. The analysis of crude data found a significantly elevated risk of preterm birth and cesarean section with twins compared to singleton gestations complicated by HDP. A significantly higher risk of small-for-gestational-age (SGA) was noted in twin pregnancies, but the effect was lost on subgroup analysis for preeclampsia. The analysis did not show any differences in 5-min Apgar score
Fields of Study & Subjects
Pregnancy and preeclampsia studies
Birth
Development
and Health
Gestational Diabetes Research and Management
Publication details
- Journal / source
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Volume
- 39
- Issue
- 1
- Pages
- 2618389–2618389
- Publication date
- 1 February 2026
- Language
- EN