Synthesis, biological evaluation, and molecular docking studies of new analogues (Schiff bases) of natural product naringenin isolated from aerial parts of Tamarix aphylla to prevent the complications linked with advanced glycation end products (AGEs)

Several chronic complications such as neuropathy, retinopathy, nephropathy, resulting from hyperglycaemia during diabetes are linked with advanced gyration end products (AGEs). The current study was undertaken on natural product, naringenin isolated from aerial parts ethanolic extract of plant Tamarix aphylla (L.) H. Karst, through column chromatography for the synthetic new analogues 2–18 to evaluate their effects against formation of (AGEs). In-vitro anti-glycation screening on these analogues against rutin as a standard revealed that analogues 4, 6, 7, 9, 10,13,16, 17 and 18 are most potent, 2, 3, 8, 12, 14 and 15 are moderately active, and 11 was least active. In MTT assay the analogues 1, 7, 8,9, 11, 12, 14, 16, and 18 were found non-toxic while 2, 3, 4, 5, 6, 10, 13, 15, and 17 were fairly toxic. Molecular docking of the most potent analogues 4, 9, 10, and 17 demonstrated the outstanding binding affinities within the α-glucosidase binding sites.