AMPK as a Double-Edged sword in cancer: role of natural compounds in its regulation
Abstract
mitochondrial stress. SAR studies highlight how chemical features such as hydroxylation and prenylation influence AMPK activation and downstream signalling. Despite encouraging anticancer evidence, challenges remain, including dose-dependent effects, limited bioavailability, and intratumoral heterogeneity. This review discusses the complex role of AMPK in cancer, the modulatory effects of natural compounds, and strategies to enhance their therapeutic potential through rational design and combination therapies.
Fields of Study & Subjects
Metabolism
Diabetes
and Cancer
Cancer
Hypoxia
and Metabolism
Flavonoids in Medical Research
Publication details
- Journal / source
- Natural Product Research
- Publisher
- Informa UK Limited
- Pages
- 1–16
- Publication date
- 10 April 2026
- Language
- EN