The role of miRNA in modulating oxidative stress in preeclampsia: current knowledge
Abstract
Preeclampsia (PE), a gestational disorder diagnosed with hypertension and proteinuria, is recognized as a significant cause of both maternal and perinatal morbidity and mortality around the world. Oxidative stress (OS) is found to act as a major positive role in PE progression, which is regulated by the function derived from multiple microRNAs (miRNAs), a group of cellular small endogenous RNAs that modulate gene expression at post-transcriptional level. This review summarizes the role of different miRNAs in the PE development, focusing on their involvement in OS regulation. In addition, the paper also discusses the current knowledge of the molecular mechanisms regarding PE and highlights the possibly therapeutic implications of targeting miRNAs in the management of this condition.
Fields of Study & Subjects
Pregnancy and preeclampsia studies
MicroRNA in disease regulation
Biomarkers in Disease Mechanisms
Publication details
- Journal / source
- RNA Biology
- Publisher
- Informa UK Limited
- Volume
- 23
- Issue
- 1
- Pages
- 1–13
- Publication date
- 27 May 2026
- Language
- EN