SNX16 functions as a nutrient-sensitive regulator of autophagosomal components recycling
Abstract
In macroautophagy/autophagy, the inner membrane of the autophagosome and its contents are degraded within the autolysosome, while outer membrane proteins are recycled via a process known as autophagosomal components recycling (ACR). ACR is mediated by the recycler complex, powered by dynein-dynactin complexes, and regulated by RAB32-family small GTPases. However, it remains unknown whether ACR is subject to nutrient signal regulation or whether additional molecular components participate in the recycler complex. Our latest research identifies SNX16 as a new component of the recycler complex and reveals that MTORC1 phosphorylates SNX16, enabling SNX16 to function as a nutrient sensor that regulates ACR.
Fields of Study & Subjects
Autophagy in Disease and Therapy
Cellular transport and secretion
Calcium signaling and nucleotide metabolism
Publication details
- Journal / source
- Autophagy
- Volume
- 22
- Issue
- 5
- Pages
- 1127–1128
- Publication date
- 28 January 2026
- Language
- EN