Synthesis of new glycoconjugates by click reaction of β-glycosyl azides and pyrimidines
Abstract
An efficient synthesis of propargyl pyrimidines connected with glucose/galactose moiety by triazole linker through Cu-catalyzed has been developed. The reaction of azido sugar derivatives (β-D-glucopyranose tetraacetate or β-D-galactopyranose tetraacetate) with propargylthio pyrimidines in the presence of CuSO4.5H2O and sodium ascorbate in THF/Isopropanol gave desired glycosyl 1,2,3-triazoles-linked pyrimidines with 81–97% yields.
Fields of Study & Subjects
Click Chemistry and Applications
Carbohydrate Chemistry and Synthesis
Chemical Synthesis and Analysis
Publication details
- Journal / source
- Journal of Sulfur Chemistry
- Publisher
- Informa UK Limited
- Volume
- 47
- Issue
- 2
- Pages
- 210–222
- Publication date
- 5 January 2026
- Language
- EN