Evaluation of antioxidant, anti-inflammatory, analgesic, and antidepressant activities of different extracts from Ammodaucus leucotrichus

This study investigates the therapeutic potential of various extracts from Ammodaucus leucotrichus (Oued Souf region) for antioxidant, anti-inflammatory, analgesic, and antidepressant activities. The ethyl acetate extract showed the strongest antioxidant effect in DPPH and FRAP assays, while the diethyl ether extract had the highest total antioxidant capacity. The butanol extract demonstrated potent anti-inflammatory activity (anti-albumin denaturation) and strong analgesic effects, achieving 84.55% inhibition in the writhing test. In the hot plate test, the diethyl ether extract yielded the longest reaction time (26.3 s). Antidepressant activity was confirmed via behavioral models: the diethyl ether extract significantly reduced immobility time in the forced swim test (10.51 s), and the butanol extract showed highest efficacy in the tail suspension test (18.52 s). These findings support the multifunctional therapeutic potential of A. leucotrichus extracts.