Fecal tryptophan metabolism predicts the development of infant eczema: a prospective longitudinal study

Gut Microbes 2026 Open access

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Authors: Naomi V. Wieser, Iris Admiraal, Roni Weiss, Mohammed Ghiboub, Mark Davids, A Lefèvre, Patrick Emond, Elizabeth A. Powell, Kathleen Sim, J. Simon Kroll, Wouter J. de Jonge, Bruno Sovran
+1 more James K. Kinross
DOI: 10.1080/19490976.2026.2655171
Cited by: 1
References: 63

Abstract

Early-life microbial metabolism of tryptophan plays a critical role in immune modulation and may influence susceptibility to inflammatory disorders such as eczema. However, longitudinal human data linking microbial tryptophan metabolism to eczema onset are limited. We conducted a prospective cohort study of 40 term-born UK infants, followed from birth to 24 months, stratified by early-onset (infants developing eczema

Fields of Study & Subjects

Tryptophan and brain disorders Gut microbiota and health Dermatology and Skin Diseases

Publication details

Journal / source
Gut Microbes
Publisher
Informa UK Limited
Volume
18
Issue
1
Pages
2655171–2655171
Publication date
7 April 2026
Language
EN