The gut–bone axis: microbial metabolism and nutritional interventions for bone health

Gut Microbes 2026 Open access

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Authors: Alba Rodriguez-Bryant, MARIA PAPAGEORGIOU, Marie-Noëlle Horcajada, Emmanuel Biver, S. Ferrari, Nicolas Bonnet
DOI: 10.1080/19490976.2026.2675093
Cited by: 3
References: 228

Abstract

), prebiotics (fructo-oligosaccharides), synbiotics, and specific dietary patterns (e.g. Mediterranean and vegetarian diets) have emerged as promising strategies to mitigate bone loss associated with aging. This review investigates the communication between the gut and bone, summarizing the underlying mechanisms and providing an updated review on microbial metabolites. Additionally, it examines recent research on probiotics and their metabolic contributions, highlighting potential gaps in the current understanding of this field.

Fields of Study & Subjects

Gut microbiota and health Bone health and osteoporosis research Probiotics and Fermented Foods

Publication details

Journal / source
Gut Microbes
Publisher
Informa UK Limited
Volume
18
Issue
1
Pages
2675093–2675093
Publication date
22 May 2026
Language
EN