Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report
Abstract
BACKGROUND: Severe oral and tongue numbness induced by piperacillin/tazobactam is extremely rare. RESULTS: A 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction. DISCUSSION: This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.
Fields of Study & Subjects
Oral and gingival health research
Blood disorders and treatments
Drug-Induced Adverse Reactions
Publication details
- Journal / source
- Future Science OA
- Publisher
- Informa UK Limited
- Volume
- 12
- Issue
- 1
- Pages
- 2653792–2653792
- Publication date
- 21 April 2026
- Language
- EN