Vaccine expression systems and maternal/neonatal factors: Impacts on hepatitis B immunization efficacy in preterm infants

Human Vaccines & Immunotherapeutics 2026 Open access

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Authors: Lu Shen, Yan Xie, Zhongkui Zhu, J. G. Wang, Yunke Qian, Huaxian LIU, Yang Yu, Wanqin Tang
DOI: 10.1080/21645515.2025.2611475
Cited by: 2
References: 36

Abstract

The global rise in preterm infants presents specific challenges for hepatitis B prevention. Although hepatitis B vaccination is recommended, detailed understanding of immunogenicity patterns and influencing factors requires further investigation. We analyzed 699 preterm infants completing the hepatitis B vaccination series to assess immunogenicity via geometric mean concentration (GMC) and seroprotection rate (SPR). The regimen was highly immunogenic, with an overall SPR of 99.43% (GMC: 986.36 mIU/mL) and 95.28% of infants achieving high-level protection (anti-HBs ≥100 mIU/mL). Though SPR was consistently high across subgroups, notable GMC variations emerged: infants with gestational age

Fields of Study & Subjects

Hepatitis B Virus Studies Vaccine Coverage and Hesitancy Hepatitis Viruses Studies and Epidemiology

Publication details

Journal / source
Human Vaccines & Immunotherapeutics
Publisher
Informa UK Limited
Volume
22
Issue
1
Pages
2611475–2611475
Publication date
20 January 2026
Language
EN