Carbapenemase-producing Klebsiella oxytoca complex in France (2017–2023): molecular epidemiology integrated with virulence and biofilm phenotypes

Emerging Microbes & Infections 2026 Open access

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Authors: Inès Rezzoug, Océane Vanparis, Joséphine Poiraud, Subidsha Nandakumaran, Delphine Girlich, Lena Latour, Haniel Defoi, Cécile Emeraud, Agnès B. Jousset, Aurelien Birer, Benoît Pilmis, Aymeric Jacquemin
+2 more Rémy A. Bonnin, Laurent Dortet
DOI: 10.1080/22221751.2026.2713319
Cited by: 1
References: 34

Abstract

OBJECTIVES: complex (KoC) isolates (2017-2023) to map species and carbapenemase distributions and identify emerging lineages. We further investigated virulence traits to understand the epidemiological success of the dominant ST-2 lineage. METHODS: infection models. RESULTS: remained the most prevalent species among the KoC. OXA-48-like enzymes were the most common carbapenemases, and two major lineages predominated: ST-141 and, far ahead, ST-2. The success of ST-2 appears linked to its low virulence combined with a strong capacity for long-term persistence. CONCLUSION: comprises a complex of distinct species whose taxonomy warrants continued revision. ST-2 circulates widely in France and, despite its limited virulence, shows remarkable persistence, making it an epidemiological important lineage.

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Infections and bacterial resistance Vibrio bacteria research studies

Publication details

Journal / source
Emerging Microbes & Infections
Publisher
Informa UK Limited
Volume
15
Issue
1
Pages
2713319–2713319
Publication date
3 August 2026
Language
EN