Development of hybrid quantum classifiers for realistic classification tasks

Abstract Hybrid quantum machine learning combines classical minimization with parameterized quantum circuits, enabling powerful learning models even on near-term quantum hardware. This work presents an evaluation of hybrid quantum machine learning classifiers using the data re-uploading framework across nine binary and multi-class classification tasks with varying geometric complexity. We compare three quantum circuit architectures, single-qubit, two-qubit, and two-qubit entangled, trained with three classical minimizers: COBYLA, Nelder-Mead, and SLSQP. Our experiments span training sizes from 1 to 200 samples and reveal that two-qubit classifiers, when paired with the SLSQP minimizer, achieve the highest overall test accuracy of 99.775% on structured tasks and strong performance (up to 89.78%) on complex multi-class pattern. Among minimizers, SLSQP consistently provides the best generalization, while entanglement improves accuracy in non-linear and fragmented tasks. By analyzing accuracy trends, generalization gaps, and confusion matrices, this study offers practical guidance for designing quantum classifiers that scale effectively and generalize well, providing a foundation for real-world Hybrid quantum machine learning applications.