Intensive blood pressure control and risks of cognitive outcomes in patients with new-onset orthostatic hypotension

Age and Ageing 2026

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Authors: Siyu Wang, Jingya Wang, Yueyue Wang, Xiaoli Xu, Haoqing Gu, Wanting Xie, Cai Ly, Junheng Zhang, Tiange Wang, Zhiyun Zhao, Mian Li, Jie Zheng
+4 more Min Xu, Jieli Lu, Yufang Bi, Yu Xu
DOI: 10.1093/ageing/afag005
Cited by: 1
References: 30

Abstract

BACKGROUND: Orthostatic hypotension (OH) increases the risk of dementia. Although intensive blood pressure (BP) lowering may have cognitive benefits regardless of baseline OH status, its effects in participants who develop OH during intervention remain unknown. METHODS: Participants of the Systolic Blood Pressure Intervention Trial (SPRINT) were randomised to either intensive treatment (systolic BP target

Fields of Study & Subjects

Cardiovascular Syncope and Autonomic Disorders Heart Rate Variability and Autonomic Control Cerebrovascular and Carotid Artery Diseases

Publication details

Journal / source
Age and Ageing
Publisher
Oxford University Press (OUP)
Volume
55
Issue
1
Publication date
1 January 2026
Language
EN