Magee Equation 3 demonstrates predictive and prognostic value for neoadjuvant chemotherapy outcomes in estrogen receptor–positive, human epidermal growth factor receptor 2–negative breast cancer

American Journal of Clinical Pathology 2026

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Authors: Jacob A. Jerome, Rachel K. Vanderschelden, Beth Z. Clark, Jing Yu, Jeffrey L. Fine, Lakshmi Harinath, Samaneh A Motanagh, Olga Navolotskaia, Tatiana M. Villatoro, Marija Balić, Charles E. Geyer, Julia Foldi
+2 more Adam Brufsky, Rohit Bhargava
DOI: 10.1093/ajcp/aqag001
Cited by: 0
References: 34

Abstract

OBJECTIVE: This study assesses the effectiveness of Magee Equation 3 (ME3) in predicting response to neoadjuvant chemotherapy (NACT) and its prognostic value. METHODS: In total, 263 clinical stage I to III estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers diagnosed between 2014 and 2020 were assessed for response to NACT. Pathologic complete response (pCR) was defined as no invasive carcinoma in the breast or regional lymph nodes. RESULTS: The pCR rate for the 4 different categories of ME3 scores (25 to

Fields of Study & Subjects

Breast Cancer Treatment Studies Breast Lesions and Carcinomas MRI in cancer diagnosis

Publication details

Journal / source
American Journal of Clinical Pathology
Volume
165
Issue
2
Publication date
3 January 2026
Language
EN