Clinical features associated with chronic lung allograft dysfunction progression in a multicenter cohort

American Journal of Respiratory and Critical Care Medicine 2026 Open access

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Authors: Jamie L. Todd, Megan L Neely, Jesse Y. Hsu, Joshua M. Diamond, M. Anderson, Edward C. Cantu, E. Clausen, Krishna Pandya, M. Oyster, L. Kalman, Courtney W. Frankel, Luke Benvenuto
+9 more Michael Combs, Gundeep Dhillon, John McDyer, Mrunal Patel, Pali Shah, Jonathan P Singer, Laurie D Snyder, Jason D. Christie, Scott M Palmer
DOI: 10.1093/ajrccm/aamaf055
Cited by: 3
References: 22

Abstract

RATIONALE: Clinical features that impact outcomes in lung recipients with chronic lung allograft dysfunction (CLAD) are uncertain and limited by existing approaches to phenotyping that rely on measures inconsistently performed or not standardized across centers. OBJECTIVE: We used data from the prospective multicenter Lung Transplant Outcomes Group (LTOG) cohort study to determine if routine, objective clinical measures at CLAD diagnosis impact progression to graft loss (death/retransplantation). METHODS: The analysis included 2386 adult lung recipients from 9 US centers. Probable CLAD was defined according to International Society for Heart and Lung Transplantation criteria. Cox models were fit for time from probable CLAD to graft loss as a function of each clinical feature of interest including CLAD stage (1-4), CLAD timing (early-onset,

Fields of Study & Subjects

Transplantation: Methods and Outcomes Renal Transplantation Outcomes and Treatments Organ and Tissue Transplantation Research

Publication details

Journal / source
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Volume
212
Issue
3
Pages
605–615
Publication date
23 January 2026
Language
EN