C54-27 Risk Factors and Outcomes Associated With Polymicrobial Infection in Ventilator-Associated Pneumonia

Abstract Background Polymicrobial pneumonia is aconcern for clinicians due to its association with increased disease poor outcomes.Evaluation and idenfying patients who have an increased risk of polymicrobial aetiology is important for the management of VAP patients. Objective We have described the clinical characteristics and outcomes of adult intubated patients with VAP,and identify the risk factors related to polymicrobial pneumonia and specifically to in-hospital mortality. Methods Our study was retrospective from a prospectively collected data including 118 intubated adult patients with VAP;91(77.0%) patients had an established aetiology. Results Polymicrobial infection was present in 38(32%) of the VAP patients with defined micribial aetiology .The most frequent polymicrobial infections were:Klebsiella pneumoniae + Staphylococcus aureus (32%),Acinotebacter baumannii +Eschericia coli(21%),S.pneumoniae +Pseudomonas aeruginosa(18%),P.aeruginosa +S.aureus(15.0%),and S.aureus+E.coli(13.0%).The age of patients with polymicrobial VAP was hgiher (p < 0.01),comorbidity index also was higher compared to monomicrobial VAP(2.45[0.58-5.86];p