Disease modification and progression in pre–chronic obstructive pulmonary disease: an official American Thoracic Society workshop report

Annals of the American Thoracic Society 2026

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Authors: Nirupama Putcha, Surya P Bhatt, Jessica M. Bon, Stephanie A Christenson, MeiLan K Han, Jerry A Krishnan, Fernando J Martinez, Richard Casaburi, James D. Crapo, Jeffrey L Curtis, Gregory B. Diette, Mark T Dransfield
+46 more Michelle N. Eakin, Ravi Kalhan, David M Mannino, María Montes de, Hugh Musick, Steven M Rowe, Benjamin M Smith, Sundeep Salvi, Xavier Soler, Jadwiga A Wedzicha, Jean Ann Wright, Prescott G Woodruff, Robert A Wise, Valerie Nash Chang, Bruce E. Miller, Courtney C. Crim, M Bradley Drummond, Courtney C. Crim, M Bradley Drummond, Bruce E. Miller, Nirupama Putcha, Surya P Bhatt, Jessica M. Bon, Richard Casaburi, Valerie Nash Chang, Stephanie A Christenson, James D. Crapo, J. Randall Curtis, Gregory B. Diette, Mark T Dransfield, Michelle N. Eakin, MeiLan K Han, Ravi Kalhan, Jerry A Krishnan, David M Mannino, Fernando J Martinez, María Montes de, Hugh Musick, Steven M Rowe, Sundeep Salvi, Benjamin M Smith, Xavier Soler, Jadwiga A Wedzicha, Jean Ann Wright, Prescott G Woodruff, Robert A Wise
DOI: 10.1093/annalsats/aaoag034
Cited by: 1
References: 156

Abstract

Chronic obstructive pulmonary disease (COPD) is a highly prevalent and burdensome disease that develops over decades. Treatments for COPD are most commonly prescribed in later stages of the disease, leaving missed opportunities to modify the course of disease at earlier stages. This workshop was conducted to promote progress in the design and conduct of clinical trials of treatments that modify progression to COPD. The aims of the workshop were to provide an operational definition of pre-COPD and to discuss the elements and design of potential clinical trials in pre-COPD. The key focus areas of this workshop included: (1) defining a study population for pre-COPD clinical trials; (2) endpoints in pre-COPD clinical trials; and (3) design considerations for pre-COPD clinical trials.

Fields of Study & Subjects

Chronic Obstructive Pulmonary Disease (COPD) Research Inhalation and Respiratory Drug Delivery Respiratory and Cough-Related Research

Publication details

Journal / source
Annals of the American Thoracic Society
Publisher
Oxford University Press (OUP)
Volume
23
Issue
5
Pages
667–688
Publication date
11 February 2026
Language
EN