Dietary purple nonsulfur bacteria increase body size of Caenorhabditis elegans

Bioscience Biotechnology and Biochemistry 2026

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Authors: W T R D Wikmal Subasinghe, Kohji Miyahara, Hitoshi Miyasaka, Hiroyuki Takeya
DOI: 10.1093/bbb/zbag012
Cited by: 0
References: 21

Abstract

We identify a novel effect in which dietary purple nonsulfur bacteria Cereibacter sphaeroides increase body size in Caenorhabditis elegans. This response requires the Toll-like receptor homolog TOL-1 and the TIR-domain adaptor TIR-1, but not the p38 MAP kinase PMK-1. Components of the DBL-1/BMP pathway, including LON-1, also contribute, revealing a new interaction between a beneficial bacterium and host growth regulation.

Fields of Study & Subjects

Genetics Aging and Longevity in Model Organisms Invertebrate Immune Response Mechanisms Gut microbiota and health

Publication details

Journal / source
Bioscience Biotechnology and Biochemistry
Volume
90
Issue
5
Pages
659–662
Publication date
17 January 2026
Language
EN