Mitochondrial NADP+-isocitrate dehydrogenase Idp1 involves CoQ biosynthesis in parallel with NAD kinase Pos5

Bioscience Biotechnology and Biochemistry 2026 Open access

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Authors: Shogo Nishihara, Yasuhiro Matsuo, Makoto Kawamukai
DOI: 10.1093/bbb/zbag059
Cited by: 1
References: 18

Abstract

Mitochondrial NADPH is synthesized by isocitrate dehydrogenase (Idp1) from NADP+ and NAD kinase (Pos5) from NADH. Coenzyme Q levels in Schizosaccharomyces pombe were decreased by deletion of idp1 and further lowered by deletion of pos5. The NADP+/NADPH ratio of the ∆idp1 strain shifted to an oxidized state. The mitochondrial NADPH pool and its redox state are critical for CoQ biosynthesis.

Fields of Study & Subjects

Coenzyme Q10 studies and effects Photosynthetic Processes and Mechanisms Enzyme Structure and Function

Publication details

Journal / source
Bioscience Biotechnology and Biochemistry
Publisher
Oxford University Press (OUP)
Volume
90
Issue
7
Pages
971–975
Publication date
22 April 2026
Language
EN