The power and limits of predicting inter-protein exon-exon interactions using protein 3D structures

Bioinformatics Advances 2026 Open access

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Authors: Jeanine Liebold, Aylin Del Moral‐Morales, Karen Manalastas-Cantos, Olga V. Tsoy, Stefan Kurtz, Jan Baumbach, Khalique Newaz
DOI: 10.1093/bioadv/vbag032
Cited by: 0
References: 58

Abstract

Abstract Motivation Alternative splicing (AS) effects on cellular functions can be captured by studying changes in the underlying protein-protein interactions (PPIs). Because AS results in the gain or loss of exons, existing methods for predicting AS-related PPI changes utilize known inter-protein exon-exon interactions (EEIs), which cover

Fields of Study & Subjects

RNA Research and Splicing Protein Structure and Dynamics Bioinformatics and Genomic Networks

Publication details

Journal / source
Bioinformatics Advances
Volume
6
Issue
1
Pages
vbag032–vbag032
Publication date
1 January 2026
Language
EN