Developments on mammalian oocyte maturation using ZHB112–113, a novel long-acting human FSH and LH recombinant fusion protein
Abstract
Ovarian stimulation medications are critical in assisted reproductive technology (ART), with growing demand for long-acting follicle-stimulating hormone (FSH). Although luteinizing hormone (LH) plays a pivotal role in oocyte maturation, recombinant long-acting LH remains underexplored. Here we develop a novel recombinant protein with an extended in vivo half-life and dual FSH and LH bioactivity to improve ovarian stimulation efficacy. This protein successfully induced ovarian stimulation in both mice and cynomolgus monkeys, confirming robust reproductive hormonal activity. The findings indicate its potential as an ovarian stimulation agent in ART, although further optimization of stimulation protocols is required.
Fields of Study & Subjects
Ovarian function and disorders
Reproductive Biology and Fertility
Hypothalamic control of reproductive hormones
Publication details
- Journal / source
- Biology of Reproduction
- Volume
- 114
- Issue
- 4
- Pages
- 1359–1370
- Publication date
- 9 January 2026
- Language
- EN