Decoding the hallmarks of GLP-1RA weight-loss super-responders

Biology Methods and Protocols 2026 Open access

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Authors: AJ Venkatakrishnan, Karthik Murugadoss, Venky Soundararajan
DOI: 10.1093/biomethods/bpag021
Cited by: 5
References: 49

Abstract

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have reshaped obesity treatment, yet weight-loss outcomes remain highly uneven in real-world care. Using a federated biomedical platform integrating 23 million de-identified U.S. patient records, we analyzed 135,349 individuals treated with GLP-1RAs and stratified them as “super responders” (>15% weight loss), “moderate responders” (5–15% weight loss), “minimal weight-loss group” (

Fields of Study & Subjects

Diabetes Treatment and Management Bariatric Surgery and Outcomes Pharmacology and Obesity Treatment

Publication details

Journal / source
Biology Methods and Protocols
Publisher
Oxford University Press (OUP)
Volume
11
Issue
1
Pages
bpag021–bpag021
Publication date
1 January 2026
Language
EN