Persistence of anti-desmoglein 3 antibodies in patients with pemphigus vulgaris in complete remission is associated with restricted isotype diversity and desmoglein 3 ectodomain recognition

British Journal of Dermatology 2026

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Authors: Billal Tedbirt, Sébastien Calbo, Léopoldine Lebourgeois, Maud Maho‐Vaillant, Claire Mignard, Manuel Fréret, Olivier Boyer, V. Hébert, P. Joly, Marie-Laure Golinski
DOI: 10.1093/bjd/ljag012
Cited by: 0
References: 7

Abstract

In pemphigus vulgaris, baseline severity and relapse correlate with anti-desmoglein 3 (anti-Dsg3) antibodies targeting ectodomains (ECs), specifically EC1–2 and EC4–5, and involving multiple IgG subclasses (two to three subclasses in 81% of patients). In contrast, patients in complete remission despite persistent anti-Dsg3 autoantibodies show limited EC recognition and predominantly single IgG subclass responses, with lower frequencies of antibody-secreting cells and reduced in vitro keratinocyte dissociation.

Fields of Study & Subjects

Autoimmune Bullous Skin Diseases Dermatology and Skin Diseases Sympathectomy and Hyperhidrosis Treatments

Publication details

Journal / source
British Journal of Dermatology
Volume
194
Issue
5
Pages
959–961
Publication date
8 January 2026
Language
EN