A novel fusion gene identified in metastatic melanoma associated with malignant transformation of a giant congenital melanocytic naevus

British Journal of Dermatology 2026

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Authors: Xiaomei Cui, Yixiao Wang, Siqi Liu, Qing Zhang, Min Gao, Shengju Yang, Xiaodong Chen
DOI: 10.1093/bjd/ljag015
Cited by: 0
References: 7

Abstract

GCMN is a major risk factor for melanoma in children, which occurs sporadically, but familial cases are rarely reported. Whole-genome sequencing results revealed the presence of a G3BP1–BRAF fusion in tumour tissue in our case. We hope that this case provides some reference for the diagnosis, prognosis and individualized treatment of newborn patients with GCMN.

Fields of Study & Subjects

Cutaneous Melanoma Detection and Management Melanoma and MAPK Pathways Neurofibromatosis and Schwannoma Cases

Publication details

Journal / source
British Journal of Dermatology
Volume
194
Issue
5
Pages
994–997
Publication date
14 January 2026
Language
EN