Impact of clinicopathological features on prognosis of thin melanomas: a retrospective cohort analysis

British Journal of Dermatology 2026 Open access

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Authors: Emma Beagles, Sara Khattab, Olivia M. Burke, Nga Nguyen, Crystal Chang, Katie Roster, Ahmad A. Rajeh, Hannah Rashdan, Cameron Moseley, Boshen Yan, Anna M. Stagner, Mia S. DeSimone
+2 more Guihong Wan, Yevgeniy R Semenov
DOI: 10.1093/bjd/ljag034
Cited by: 1
References: 6

Abstract

Using a large multi-institutional cohort of patients with thin melanomas, our study identified that while predictive of improved prognosis in later stage disease, the presence of tumour-infiltrating lymphocytes is associated with poorer outcomes in patients with thin melanomas. Increasing mitotic rate, Charlson Comorbidity Index, absence of radial growth phase and self-pay/no insurance are also significantly associated with poorer outcomes, while tumour thickness, historically one of the most important prognostic features, is not independently associated with recurrence or mortality. This study elucidates novel risk factors that could prognosticate recurrence or mortality among thin melanomas and can be used to enable more personalized surveillance and therapeutic strategies.

Fields of Study & Subjects

Cutaneous Melanoma Detection and Management Melanoma and MAPK Pathways Immunotherapy and Immune Responses

Publication details

Journal / source
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Volume
194
Issue
5
Pages
976–979
Publication date
30 January 2026
Language
EN