Comment on enhancing reproducibility in treat-to-target dose adjustment studies
Abstract
This Letter to the Editor raises two key criticisms and suggestions regarding a ‘targeted therapy’ trial of upadacitinib for atopic dermatitis published in the British Journal of Dermatology. Clarifying the reportable numerical inconsistencies and strengthening the linkage between decision rules and analytic estimates would materially enhance the study’s reproducibility and clinical translation.
Fields of Study & Subjects
Dermatology and Skin Diseases
Statistical Methods in Clinical Trials
Meta-analysis and systematic reviews
Publication details
- Journal / source
- British Journal of Dermatology
- Volume
- 194
- Issue
- 6
- Pages
- 1196–1196
- Publication date
- 11 February 2026
- Language
- EN