The effect of the plant-derived prenylated flavonoid icariin on acne vulgaris and atrophic acne scars

British Journal of Dermatology 2026

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Authors: Dong Hyo Kim, Ji Young Yoon, Jun Hyo Lee, Jeewoo Kang, Seong Rae Kim, Tae Min Kim, Dae Hun Suh
DOI: 10.1093/bjd/ljag062
Cited by: 2
References: 8

Abstract

Given the high prevalence of acne vulgaris and atrophic acne scars, particularly among adolescents and young adults, well-tolerated noninvasive treatments are needed. This randomized split-face clinical trial demonstrated the therapeutic potential of icariin, a flavonoid from the Epimedium species. Topical application of icariin significantly reduced acne and atrophic scar severity without adverse events by modulating acne-related pathophysiology, including inflammation and abnormal keratinization, while promoting extracellular matrix synthesis.

Fields of Study & Subjects

Medicinal Plant Pharmacodynamics Research Hair Growth and Disorders Acne and Rosacea Treatments and Effects

Publication details

Journal / source
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Volume
194
Issue
5
Pages
981–983
Publication date
17 February 2026
Language
EN