Merkel cells release ATP in response to mechanical stimulation to mediate paracrine signalling

British Journal of Dermatology 2026

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Authors: Mi Seon Seo, Kyung Chul Shin, Eustache Ntigura, Jin Ryeol An, Shadi Golpasandi, Yeji Lim, Hyeryeong Lee, Solah Park, Juewon Kim, Doyoung Byun, Shin-Young Ryu, Sang Woong Park
+1 more Young Min Bae
DOI: 10.1093/bjd/ljag067
Cited by: 0
References: 8

Abstract

Human Merkel cells release ATP in response to mechanical stimulation, activating neighbouring Merkel cells through purinergic receptors. This study reveals a previously unrecognized paracrine signalling mechanism within epidermal touch domes that may modulate tactile sensitivity. These findings provide new insight into non-neuronal sensory communication and potential roles in age-related or pathological sensory changes.

Fields of Study & Subjects

Adenosine and Purinergic Signaling Ion Channels and Receptors Pain Mechanisms and Treatments

Publication details

Journal / source
British Journal of Dermatology
Volume
194
Issue
6
Pages
1173–1175
Publication date
22 February 2026
Language
EN