Collagen I–discoidin domain receptor 1 (DDR1) signalling as a driver of keloid inflammation: mechanistic expansion of the adenosine diphosphate ribosylation factor 6–DDR1 axis
Abstract
This letter critically evaluates the recent study by Hu et al. on collagen I–discoidin domain receptor 1 (DDR1) signalling in keloid inflammation, highlighting its role in activating NF-κB and STAT3 pathways. We discuss the potential of dual-target therapy involving DDR1 and adenosine diphosphate ribosylation factor 6 (ARF6) inhibition and identify areas for further exploration, including the involvement of co-receptors, intermediate signalling pathways and collagen remodelling. These insights may guide future therapeutic strategies for keloid treatment.
Fields of Study & Subjects
Dermatologic Treatments and Research
Wound Healing and Treatments
Fibroblast Growth Factor Research
Publication details
- Journal / source
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Volume
- 195
- Issue
- 2
- Pages
- 372–373
- Publication date
- 30 March 2026
- Language
- EN