Context, not class, may be the key signal in systemic Janus kinase inhibitor exposure in mycosis fungoides/Sézary syndrome
Abstract
This letter argues that the apparent risk signal associated with systemic Janus kinase inhibitors in mycosis fungoides/Sézary syndrome should be interpreted in light of clinical context, heterogeneous case sources, and diagnostic uncertainty. It highlights late-onset or erythrodermic dermatitis and the post-transplant setting as higher-risk contexts, while cautioning against assuming a uniform harmful class effect.
Fields of Study & Subjects
Cutaneous lymphoproliferative disorders research
Histiocytic Disorders and Treatments
Sarcoidosis and Beryllium Toxicity Research
Publication details
- Journal / source
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Volume
- 195
- Issue
- 3
- Pages
- 549–549
- Publication date
- 14 June 2026
- Language
- EN