Site-specific relapse in pemphigus is associated with localized tissue-resident memory T-cell enrichment
Abstract
Pemphigus relapse shows a nonrandom, site-specific pattern, with recurrent lesions preferentially occurring at previously affected anatomical locations. In a retrospective cohort of 105 patients, we found that spatial overlap between new-onset and relapse sites significantly exceeded random expectation and was independent of circulating autoantibody levels. Recurrent lesions were enriched for CD4+CD69+ and CD8+CD103+ tissue-resident memory T cells, suggesting a role for localized immune memory in disease recurrence.
Fields of Study & Subjects
Autoimmune Bullous Skin Diseases
Sympathectomy and Hyperhidrosis Treatments
Genetic and rare skin diseases.
Publication details
- Journal / source
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Volume
- 195
- Issue
- 5
- Pages
- 856-858
- Publication date
- 23 July 2026
- Language
- EN