High-dimensional overfitting and noisy diagnostic labels: reconsidering the role of BRAF copy number in primary dermal melanoma
Abstract
We address a fundamental ground-truth fallacy in the study’s design: utilizing admittedly imperfect clinical diagnoses as the absolute standard to train classification models creates a circular logic. We propose that BRAF amplification in these cases more likely serves as a diagnostic corrective marker for misclassified dermal metastases, rather than a true prognostic indicator for isolated primary dermal melanoma.
Fields of Study & Subjects
Cutaneous Melanoma Detection and Management
Melanoma and MAPK Pathways
AI in cancer detection
Publication details
- Journal / source
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Publication date
- 22 August 2026
- Language
- EN