Can a treatment-responsive molecular clock independently timestamp psoriatic skin?
Abstract
This letter discusses a methodological concern in the transcriptomic analysis by Zhan et al., in which ZeitZeiger was used to infer sampling time in psoriatic skin datasets. Because several treatment-responsive clock genes may also contribute to molecular time prediction, additional diagnostics are needed to distinguish restoration of temporal immune organization from treatment-related predictor drift.
Fields of Study & Subjects
Dermatology and Skin Diseases
Psoriasis: Treatment and Pathogenesis
Circadian rhythm and melatonin
Publication details
- Journal / source
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Volume
- 195
- Issue
- 5
- Pages
- 885-886
- Publication date
- 27 August 2026
- Language
- EN