Clinical and molecular landscape of surgically resected early onset pancreatic cancer

British journal of surgery 2026 Open access

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Authors: Stephan Dreyer, Adam Bryce, Fieke Froeling, Shannon Jackson, Leonor Santana, Euan J. Dickson, Maria Coats, Colin McKay, David J. Holroyd, Andrew Victor Biankin, Nigel B. Jamieson, David Kuang-Fu Chang
DOI: 10.1093/bjs/znag032
Cited by: 1
References: 28

Abstract

BACKGROUND: The increase in incidence of early-onset pancreatic cancer (EOPC) is of concern and poorly understood. The aim of this study was to investigate the clinical outcomes of surgically resected patients with EOPC and the potential molecular heterogeneity between EOPC and late age-onset disease. METHODS: A retrospective cohort study was conducted, with clinical, pathological, and survival outcome data obtained from two large independent prospective cohorts curated by the Australian Pancreatic Genome Initiative (APGI) and the West of Scotland Pancreatic Unit (Glasgow Royal Infirmary) between 1997 and 2022. Patients were categorized into two age groups (

Fields of Study & Subjects

Pancreatic and Hepatic Oncology Research Neuroendocrine Tumor Research Advances Pancreatitis Pathology and Treatment

Publication details

Journal / source
British journal of surgery
Publisher
Oxford University Press (OUP)
Volume
113
Issue
5
Publication date
19 March 2026
Language
EN