Skin biology and research

Clinical and Experimental Dermatology 2026

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Authors: Nada Khalil, Khawar Hussain
DOI: 10.1093/ced/llag011
Cited by: 0
References: 4

Abstract

A 45-year-old man presented with painful oral erosions and flaccid blisters on the trunk, with a positive Nikolsky sign. Histopathology revealed intraepidermal acantholysis. Direct immunofluorescence demonstrated intercellular IgG and C3 deposition in a ‘fishnet’ pattern, confirming pemphigus vulgaris. To determine the specific target antigens, the patient’s serum was analysed using a technique that separates epidermal proteins by molecular weight and detects bound autoantibodies.

Fields of Study & Subjects

Autoimmune Bullous Skin Diseases Skin Diseases and Diabetes Skin and Cellular Biology Research

Publication details

Journal / source
Clinical and Experimental Dermatology
Volume
51
Issue
6
Pages
1146–1147
Publication date
6 January 2026
Language
EN