Overcoming genetic drivers in alopecia areata: hair regrowth in a patient with AIRE gene mutation (autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy, APECED syndrome) treated with ruxolitinib

Clinical and Experimental Dermatology 2026

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Authors: James W.D. Irvine, Susan Holmes
DOI: 10.1093/ced/llag022
Cited by: 0
References: 5

Abstract

We report complete hair regrowth in a patient with autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy-associated alopecia areata (AA) following treatment with a Janus kinase inhibitor (JAKi). This highlights the effectiveness of JAKi in treating AA associated with genetic disease as well as sporadic AA.

Fields of Study & Subjects

Hair Growth and Disorders Dermatology and Skin Diseases dental development and anomalies

Publication details

Journal / source
Clinical and Experimental Dermatology
Volume
51
Issue
7
Pages
1291–1292
Publication date
10 January 2026
Language
EN