Ashy dermatosis-like hyperpigmentation limited to the arms associated with osimertinib therapy
Abstract
A 66-year-old man receiving osimertinib for lung adenocarcinoma developed multiple asymptomatic slate-grey macules on photo-exposed forearms. Histopathology showed basal vacuolar change with pigment incontinence. Recognizing this drug-related pattern allows continuation of effective anticancer therapy.
Fields of Study & Subjects
Colorectal Cancer Treatments and Studies
Melanoma and MAPK Pathways
Chemotherapy-related skin toxicity
Publication details
- Journal / source
- Clinical and Experimental Dermatology
- Publisher
- Oxford University Press (OUP)
- Volume
- 51
- Issue
- 7
- Pages
- 1299–1300
- Publication date
- 13 February 2026
- Language
- EN