Needle-free transdermal delivery of lipid-based ionic liquid-mediated laminarin-loaded solid-in-oil nanodispersion for enhanced antibody response

Chemistry Letters 2026

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Authors: Md Shahin Sarker, Yoshirou Kawaguchi, Rie Wakabayashi, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto
DOI: 10.1093/chemle/upag127
Cited by: 1
References: 30

Abstract

Abstract Herein, a lipid-based ionic liquid-mediated laminarin-loaded solid-in-oil nanodispersion was successfully developed. The developed dispersion exhibited favorable biocompatibility in both in vitro and in vivo evaluations, and showed significantly enhanced in vitro skin permeability. Notably, transdermal immunization with the nanodispersion elicits ovalbumin-specific antibody responses comparable to those achieved through the subcutaneous injection of ovalbumin at an equivalent dose. These findings highlight the potential of laminarin-loaded nanodispersion as a promising platform for noninvasive, needle-free transdermal vaccination.

Fields of Study & Subjects

Advancements in Transdermal Drug Delivery Advanced Drug Delivery Systems Pickering emulsions and particle stabilization

Publication details

Journal / source
Chemistry Letters
Publisher
Oxford University Press (OUP)
Volume
55
Issue
7
Publication date
22 June 2026
Language
EN