Point-of-Care Urine Tenofovir Drug-Level Feedback Counseling Improves Long-Term Pre-exposure Prophylaxis Adherence for US Men Who Have Sex With Men in Pilot RCT

Clinical Infectious Diseases 2026 Open access

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Authors: Matthew A. Spinelli, Leah Davis Ewart, Emily Jayne Ross, Megan J. Heise, Renata Buccheri, Carlos Henrique Valente Moreira, Shivani Mahuvakar, David V. Glidden, K. Rivet Amico, Emily A. Arnold, Warren C. Rodrigues, Hideaki Okochi
+5 more Jennifer Knapp Manuel, Margaret A. Handley, Susan Buchbinder, Adam W. Carrico, Monica Gandhi
DOI: 10.1093/cid/ciag080
Cited by: 0
References: 12

Abstract

A remote, motivational interviewing-informed intervention using self-administered point-of-care urine tenofovir testing improved long-term pre-exposure prophylaxis (PrEP) adherence among young US men-who-have-sex-with-men in a pilot randomized trial. Participants increased hair tenofovir levels by 1-2 tablets weekly, with high feasibility and acceptability, supporting further implementation.

Fields of Study & Subjects

HIV/AIDS Research and Interventions HIV Drug Use Sexual Risk HIV/AIDS drug development and treatment

Publication details

Journal / source
Clinical Infectious Diseases
Volume
82
Issue
5
Pages
e992–e995
Publication date
7 February 2026
Language
EN