Multisystem Inflammatory Syndrome in Children, United States, 2023–2024

Clinical Infectious Diseases 2026

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Authors: Ami B. Shah, Katherine N. Lindsey, Laura Divens Zambrano, Rebecca J. Free, Regina M. Simeone, Angela P Campbell, Anna R Yousaf, the MIS-C Surveillance Authorship Group, Xandy Peterson Pompa, Haytham Safi, Adrianna Stanley-Downs, Deva Borthwick
+41 more Jacqueline Denning, Tiffany White, Gabrielle Williams, Walaa Elbedewy, Anjali Vyas, Kathryn Turner, Megan Crutchfield, Mallory Sinner, Stacy Davidson, G. V. Richardson, Julie Hand, Chloe Manchester, Anna Krueger, Juliana Jacoboski Duncan, Libby Reeg, Cole Burkholder, Paige D’Heilly, Sarah Lim, Theresa S. Kittle, Alexandra Berkley, Jessica Goswitz, Hannah Ball, Sai Paritala, Saadiah Khan, Nagla S. Bayoumi, Christopher Gil, Donna Gowie, Ty Lautenschlager, Jeremy Budd, Allison H. Longenberger, Carmen J Rodriguez Caquias, Andrew Torres, Abby L. Berns, Karen Luther, LaKita D Johnson, Hani Mohamed, Amanda Hartley, Danita Crear, TaKindra Westbrook, Amanda Dodd, Johanna Bosse
DOI: 10.1093/cid/ciag259
Cited by: 1
References: 15

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is rare following SARS-CoV-2 infection, but sporadic cases continue to be reported. This analysis of cases from 2023-2024 shows little change in clinical presentation between years. Among vaccine age-eligible children, 99% of cases occurred in children who were not up-to-date with COVID-19 vaccination.

Fields of Study & Subjects

Kawasaki Disease and Coronary Complications SARS-CoV-2 and COVID-19 Research COVID-19 Impact on Reproduction

Publication details

Journal / source
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Publication date
24 April 2026
Language
EN