Intra-individual fluctuations in alkaline phosphatase predict mortality and CKD progression: insights from a large CKD cohort

Clinical Kidney Journal 2026 Open access

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Authors: Yaerim Kim, Ping-Hsun Wu, Soie Kwon, Seung Hyun Han, Jeonghwan Lee, Jeonghwan Lee, Ming‐Yen Lin, Yi-Wen Chiu, Nak‐Hoon Son, Jin Hyuk Paek, Dong Ki Kim, Seungyeup Han
+4 more Chun Soo Lim, Shang-Jyh Hwang, Jung Pyo Lee, Jung Pyo Lee
DOI: 10.1093/ckj/sfag022
Cited by: 1
References: 40

Abstract

ABSTRACT Background Elevated alkaline phosphatase (ALP) levels are associated with mortality. However, the significance of ALP variability, particularly in chronic kidney disease (CKD), has not been well explored. This study examined the associations of baseline ALP and its variability with all-cause mortality and end-stage kidney disease (ESKD) in patients with CKD. Methods This retrospective cohort study analyzed data from tertiary hospitals in Taiwan and Korea (2001–2021). Adults with CKD, defined by at least two estimated glomerular filtration rate (eGFR) values

Fields of Study & Subjects

Alkaline Phosphatase Research Studies Parathyroid Disorders and Treatments Kidney Stones and Urolithiasis Treatments

Publication details

Journal / source
Clinical Kidney Journal
Publisher
Oxford University Press (OUP)
Volume
19
Issue
3
Pages
sfag022–sfag022
Publication date
2 February 2026
Language
EN