Short versus long corticosteroid therapy for immune checkpoint inhibitors–induced acute tubulointerstitial nephritis

Clinical Kidney Journal 2026 Open access

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Authors: Pilar Auñón, Vanessa Lopes, Irene Minguez, Pablo Pérez-Romero, Katherine Peña-Ordónez, Mara Serrano-Soto, Mariana Rivera, Fabiola Alonso, Verónica R Mercado, Candela Moliz, Virginia Cabello, Enrique Morales
+2 more Eduardo Gutiérrez, Teresa Cavero
DOI: 10.1093/ckj/sfag076
Cited by: 1
References: 32

Abstract

ABSTRACT Background Immune-mediated acute tubulointerstitial nephritis (ICI-AIN) is the most common form of immune-mediated renal toxicity induced by immune checkpoint inhibitors (ICIs). It has an excellent response to corticosteroids, but there is no consensus on the most suitable steroid regimen. Methods A multicentre retrospective study including 62 patients diagnosed with ICI-AIN treated with corticosteroids was conducted. Patients were categorized into two groups based on the duration of corticosteroid treatment: ‘short course of steroids (SCS)’ (

Fields of Study & Subjects

Nephrotoxicity and Medicinal Plants Acute Kidney Injury Research Chemotherapy-induced organ toxicity mitigation

Publication details

Journal / source
Clinical Kidney Journal
Publisher
Oxford University Press (OUP)
Volume
19
Issue
4
Pages
sfag076–sfag076
Publication date
4 March 2026
Language
EN