P0910 Dietary Micronutrient Gaps in IBD: Differences Between Active Disease and Remission

Abstract Background IBD patients face a high risk of malnutrition, especially those with Crohn’s disease, where micronutrient absorption is often impaired. Deficiencies are common in both active and quiescent disease and are associated with poorer outcomes.1 Nutrition may also contribute to IBD onset and flares. IBD likely results from genetic, immune, microbial, and environmental interactions. Diet influences intestinal inflammation through effects on the microbiota, immune responses, and epithelial barrier.2 Thus, inadequate micronutrient intake may initiate a cycle in which low protective nutrient levels affect disease activity, while inflammation and malabsorption further worsen deficiencies. Methods A cross-sectional study was conducted in patients receiving ambulatory care at a day-care IBD unit, who were consecutively recruited. Dietary intake was assessed using a self-administered, semi-quantitative food frequency questionnaire validated for the adult Portuguese population.3,4 Blood and fecal samples were collected. The primary outcome was daily dietary intake of micronutrients (vitamins and minerals) according to disease activity. Clinical activity was assessed using the PMS for ulcerative colitis and the HBI for Crohn’s disease, and biological activity was evaluated via fecal calprotectin and C-reactive protein. Patients were considered in remission if PMS≤2 or HBI ≤4, fecal calprotectin