Cardiac damage across moderate to severe aortic stenosis

Abstract Background Extra-aortic cardiac damage staging has been increasingly recognized for its prognostic value in aortic stenosis (AS). However, it is still unknown whether it might help identify high risk patients across moderate and severe AS. Aim of this study was therefore to investigate whether this staging is additionally associated with outcome in patients with moderate AS compared to asymptomatic severe AS. Methods Patients were included from a multicentre international registry and categorized into five extra-aortic cardiac damage stages: Stage 0-no cardiac damage; Stage 1-left ventricular (LV) damage:LV hypertrophy, or E/e′ >14, or LV ejection fraction 34 mL/m²), atrial fibrillation (AF), or significant mitral regurgitation; Stage 3-pulmonary hypertension:systolic pulmonary artery pressure (SPAP) ≥60 mmHg or significant tricuspid regurgitation; Stage 4-right ventricular dysfunction:tricuspid annular plane systolic excursion